Tuesday, June 4, 2002

GUEST SPEAKER: Prof. Leon Rosenberg

"What is Health Worth?"

Leon E. Rosenberg, M.D. has faculty appointments in the Department of Molecular Biology, as well as the Woodrow Wilson School of Public and International Affairs. His career experiences reflect involvement with government, academia, and industry. In 1959 he began a six-year association as an investigator with the metabolism service of the National Cancer Institute. In 1965, he was appointed assistant professor of Medicine at Yale. He was named professor of Human Genetics, Pediatrics, and Medicine in 1972, the same year he helped establish the Department of Human Genetics at Yale and became its first chairman. Dr. Rosenberg was the dean of the Yale University School of Medicine from 1984 to 1991. Between 1991 and 1998 he worked for the Bristol-Myers Squibb Company as President of the Pharmaceutical Research Institute and as Senior Vice President to Scientific Affairs.

He currently serves on the Boards of Directors of the Lovelace Respiratory Research Institute, Research!America, the Association for Patient-Oriented Research, Karo Bio AB, Pharmaceutix, Ltd., and Medicines for Malaria Venture Cellular Genomic, Inc. He recently chaired a congressionally-mandated committee of the Institute of Medicine charged with assessing research priority-seeking at the National Institutes of Health (NIH). On October 26, 1998, Dr. Rosenberg presented the second annual Shannon Lecture at the NIH.

A specialist in inherited metabolic disorders in children, Dr. Rosenberg and his colleagues conducted pioneering laboratory investigations into the molecular basis of several inherited disorders of amino acid and organic acid metabolism. For example, they discovered that children with a potentially lethal disorder of organic acid metabolism suffer from defective metabolism of vitamin B12. They went on to demonstrate that supplements of B12 were remarkably beneficial clinically. Using another rare disorder as a model system, he and his associates provided crucial insights into the basic mechanism by which proteins synthesized in the cytoplasm are transported into mitochondria.

Dr. Rosenberg has been a member of the National Academy of Sciences since 1985 and of the Institute of Medicine since 1982. He received the Borden Award from the American Academy of Pediatrics for outstanding achievement in research relating to infant nutrition in 1973. Active in professional societies, he is a fellow of the American Academy of Arts and Sciences and the American Association for the Advancement of Science. He is a past president of the American Society of Human Genetics and of the Association of American Physicians.

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Last updated 23 May, 2002