Abdominal pain and distension

The aim of this topic is to review the pathophysiology of intestinal obstruction. It also provides an opportunity to review the pathology and clinical consequences of colorectal carcinoma.

Learning objectives

At the completion of this topic you should be able to:

  1. Explain the pathogenesis of the more common causes of mechanical intestinal obstruction, including neoplasms, herniae, adhesions, volvulus, intussusception and inflammatory strictures.
  2. Describe the pathophysiology of adynamic intestinal obstruction, including postoperative paralytic ileus, bowel infarction and toxic megacolon.
  3. Describe the general clinical features of intestinal obstruction and how they may indicate the level of obstruction.
  4. Discuss the pathogenesis of fluid and electrolyte abnormalities in bowel obstruction.
  5. List factors predisposing to the development of colorectal carcinoma.
  6. Describe the clinical features of colorectal carcinoma and how they may be related to the site of the tumour.
  7. Discuss the mode of spread of colorectal carcinoma and the Astler-Coller staging system.

Trial exam questions:
  1. Discuss the following statement: "Colorectal carcinoma is an excellent example of the multi-step theory of carcinogenesis."
  2. Write brief notes on the factors influencing the prognosis in colorectal carcinoma.

Case protocol associated with this topic - 1

Back to Tutorial Timetable