Jaundice

The aim of this topic is to review the common causes of hepatic injury and the metabolic consequences of such disease.

Learning objectives:

At completion of this topic you should be able to:

1. Describe the metabolism of haem and excretion of its breakdown products.
2. Outline the metabolic consequence of hepatic failure.
3. Describe the clinical features of viral hepatitis. Compare and contrast disease caused by the hepatotropic viruses HAV, HBV, HCV, HDV and HEV.
4. Discuss the pathogenesis, clinical features and sequelae of chronic hepatitis, both viral-associated and autoimmune.
5. Outline the spectrum of liver disease associated with alcohol abuse.
6. List factors predisposing to the development of cirrhosis of the liver.
7. Discuss the pathogenesis of the clinical features and complications of cirrhosis.
8. Describe the metabolic consequences of obstruction to the biliary tree.
9. Discuss the common tests used to evaluate hepatic function and the pathophysiological basis of abnormalities detected by these tests.
10. Recognise the usual pattern of liver function test abnormalities observed in hepatitis, hepatic infiltration, biliary obstruction and hepatic failure.

1. Discuss the pathophysiology of four potentially lethal complications of cirrhosis.
2. Describe the epidemiology and clinical consequences of Hepatitis B infection.

Other relevant protocol - 40

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