Proteinuria

The aim of this topic is to examine the common causes of proteinuria, and their clinical implications.

Learning objectives:

At the completion of this topic you should be able to:

1. Describe the common causes of proteinuria, and contrast tubular and glomerular forms of proteinuria.
2. Define the term "nephrotic syndrome".
3. List the common causes of the nephrotic syndrome in children, adolescents and adults.
4. Outline the investigation of a patient found to have significant proteinuria on urinalysis.
5. List the recognised aetiological agents in membranous glomerulonephritis.
6. Explain the pathogenesis of the main complications of the nephrotic syndrome.
7. Describe the renal complications of diabetes mellitus and systemic lupus erythematosus.
8. Outline the pathophysiology of glomerulonephritis in terms of underlying mechanisms of immunological injury.

1. What is the "nephrotic syndrome", and which are the common underlying lesions?
2. Outline an appropriate sequence of investigations to determine the cause of proteinuria.

Other relevant protocol - 30

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